CXCL9, but not CXCL10, Promotes CXCR3-Dependent Immune-Mediated Kidney Disease
نویسندگان
چکیده
منابع مشابه
CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.
Chemokines are instrumental in macrophage- and T cell-dependent diseases. The chemokine CCL2 promotes kidney disease in two models of immune-mediated nephritis (MRL-Fas(lpr) mice and the nephrotoxic serum nephritis model), but evidence suggests that multiple chemokines are involved. For identification of additional therapeutic targets for immune-mediated nephritis, chemokine ligands and recepto...
متن کاملInduction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells
Cathepsin B (CTSB) is a lysosomal cysteine protease that has been linked to the progression of breast cancer, for example by activation of other proteases and tumor-promoting cytokines, thereby supporting tumor invasion and metastasis. Previously, it was shown that CTSB cleaves and inactivates C-X-C motif chemokine receptor 3 (CXCR3) chemokines. As CXCR3 ligands have been demonstrated to induce...
متن کاملIntracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function.
The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC). Previously, we have found that of the three ligands, CXCL11 is the most potent inducer of CXCR3 internalization and is the physiologic inducer of CXCR3 internalization after T cell contact with activated endot...
متن کاملRole of CXCR3/CXCL10 Axis in Immune Cell Recruitment into the Small Intestine in Celiac Disease
Lymphocytic infiltration in the lamina propria (LP), which is primarily composed of CD4(+) Th1 cells and plasma cells, and increased numbers of intraepithelial lymphocytes (IELs), is a characteristic finding in active celiac disease (CD). Signals for this selective cell recruitment have not been fully established. CXCR3 and its ligands, particularly CXCL10, have been suggested to be one of the ...
متن کاملIncreased expression of Cxcr3 and its ligands, Cxcl9, and Cxcl10, during the development of alopecia areata in the mouse
Caroline G. McPhee1, F. Jason Duncan2, Kathleen A. Silva1, Lloyd E. King Jr.3, Harm HogenEsch4, Derry C. Roopenian1, Helen B. Everts2, and John P. Sundberg1,3 1The Jackson Laboratory, Bar Harbor, ME 2Department of Nutrition, The Ohio State University, Columbus, OH 3Division of Dermatology, Vanderbilt University, Nashville, TN 4Department of Comparative Pathobiology, Purdue University, West Lafa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2008
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007111179